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Alterations in NAD metabolism are critically linked to neurodegenerative disorders, as the accumulation of nicotinamide mononucleotide exerts pro-degenerative effects on axons, whereas enhancing its metabolism may rescue axons from degeneration (53)

Biomacromolecules 21 , 52415255 (2020)

Splitting the daily dose into morning and evening injections maintains steadier peptide availability for ongoing tissue support

4.1.2 Injectables and CNS-targeting nanotherapeutics for neurodegenerative disease 4.1.2.1 Injectable cytokine releasing hydrogels Injectable hydrogels formed from natural polymers can encapsulate and gradually release anti-inflammatory cytokines at CNS sites, creating a confined immunoregulatory niche

All of the studies included had parallel-study designs except two which were crossover trials [26, 27]